其实可以直接将图片存储在文件系统中，然后在mysql中只存储文件路径就可以了

from sqlalchemy.dialects.sqlite import BLOB

class Sample(Base):
    __tablename__ = 'sample'
    id = Column(Integer, primary_key=True)
    image = Column(BLOB)

这个应该是定义了一个二进制列，然后你只要把图片转为二进制保存应该就可以了。

具体可以参考下面：
http://stackoverflow.com/ques...

可以把图片文件转换为base64编码然后存入到数据库。具体看示例

# -*- coding: utf-8 -*

from sqlalchemy import Column, String, create_engine, LargeBinary
from sqlalchemy.orm import sessionmaker
from sqlalchemy.ext.declarative import declarative_base
import base64

Base = declarative_base()


class User(Base):
    __tablename__ = 'user'

    id = Column(String(20), primary_key=True)
    name = Column(String(20))
    image = Column(LargeBinary)


img = open("1111.png", "rb")
img = base64.b64encode(img.read())

engine = create_engine('mysql://root:123456@localhost:3306/test')
DBSession = sessionmaker(bind=engine)
session = DBSession()

new_user = User(id='1', name='test', image=img)
session.add(new_user)
session.commit()

# 查询刚刚存入放入图片
user = session.query(User).filter(User.id == '1').one()
image = base64.b64decode(user.image)

with open("test.png", "wb") as f:
    f.write(image)

session.close()